For example, genes with Motif 1 in Molecular Mechanisms of Cancer pathway include MAPK1, BRAF, SMAD2, FZD5, FZD8, NOTCH1 and LRP1, whereas genes with Motif 2 and/or Motif3 in the same pathway include LRP5, LRP6, MDM2, CTNND1, SMAD3, SMAD4 and SMAD7. The gene discussed is SMAD2; the disease is cancer.