Instead, we identified a significant interaction of gender with these three SNPs in the EDNRA gene and with these two SNPs in the EDN1 gene, regular exercise with rs1395821 and rs5333 in the EDNRA gene, and obesity with rs5333 in the EDNRA gene in Han Chinese subjects. This evidence concerns the gene EDN1 and obesity due to melanocortin 4 receptor deficiency.