A study conducted in Japanese patients with essential hypertension investigated the relationship between 11 SNPs of ET-1 family genes (including three in EDN1, one in EDNRA) and atherosclerotic changes and found a significant correlation between mean carotid IMT and EDNRArs5333 in male, but not female, hypertensive patients [32]. The gene discussed is EDNRA; the disease is essential hypertension.