EDNRA and obesity due to melanocortin 4 receptor deficiency: In conclusion, the current study identified three variants (rs1395821, rs1878406, rs5333) in the EDNRA gene and two variants (rs1800541 and rs5370) in the EDN1 gene that interacted with gender; two in the EDNRA gene (rs1395821 and rs5333) interacted with regular exercise; and one in the EDNRA gene (rs5333) interacted with obesity on carotid IMT in Han Chinese participants from the TCHS.