Intriguingly, in addition to the 3 clinical cases showing a correlation between MAPK7 amplification and high level protein expression (IHC3+), we also identified a further 12 cases with IHC3+ protein staining in the absence of MAPK7 amplification, raising the question of whether MAPK7 gene amplification, protein overexpression, or both, are required for driving tumor proliferation. Here, MAPK7 is linked to neoplasm.