Fluorescent in situ hybridization (FISH) analysis identified high level MAPK7 gene amplification in 4 % (3/74) of NSCLC (enriched to 6 % (3/49) in squamous cell carcinoma) and 2 % (2/95) of sqEC (Fig. 1 and Table  1). Here, MAPK7 is linked to non-small cell lung carcinoma.