GHRL and Prader-Willi syndrome: Interestingly, this may also tie‐in with endocrine changes seen in PWS, as artificially increased levels of ghrelin in healthy non‐obese subjects induced similar brain activation in response to food as fasting (Goldstone et al., 2014), and indeed to those seen in PWS (Miller et al., 2007; Dimitropoulos & Schultz, 2008).