Whilst it has been suggested that increased ghrelin may not be causal to the abnormal eating patterns observed in PWS, but perhaps reflects a compensatory effect, elevated circulating levels of ghrelin may still underpin the hyperphagia/failed‐satiety response seen here, as well as that seen in patients with PWS (Purtell et al., 2011) and in other models (Bischof et al., 2007; Ding et al., 2008). Here, GHRL is linked to Prader-Willi syndrome.