Otherfindings are as follows: MMP changes in TIMP profile, which favor decreased ECMdegradation (decreased MMP-2, MMP-9 and MMP-13 and increased TIMP-1), are associatedwith left ventricular hypertrophy and diastolic dysfunction; and increased TIMP-1predicted the presence of chronic heart failure11. This evidence concerns the gene TIMP1 and left ventricular hypertrophy.