Although prostate biopsy is favored as a histological diagnosis of prostate cancer for patients with a PSA level greater than 4 ng/ml, in almost one of two patients symptoms occur caused by biopsy, like fever, haematuria, haematochezia or haemoejaculate and often results in loss of toleration for repeating biopsy.[2, 35] Moreover, diagnostic methods, which are able to distinguish between malignant state and benign state, also reduce the risk of patients`undertreatment and overtreatment. This evidence concerns the gene KLK3 and Familial prostate cancer.