PRRT2 and cancer: MARCKSL1 is a member of the MARCKS family, a group of proteins involved in the calmodulin (CaM) signaling pathway, the protein kinase C (PKC) signaling pathway, and in the regulation of the actin cytoskeleton.[27] MARCKS can be associated with cancer development and tumorgenesis.[28] MARCKS was previously been reported to be a target of miRNA-21 in prostate cancer cells.[29] Further studies have to elucidate the exact role of MARCKS in the development of prostate cancer.