BRCA1 and breast cancer: For example, we found that DEGs of BRCA1 knockdown in the human breast cancer cell line MCF−7 (GPA ID: GPAHSA000935) were significantly enriched in the JAK-STAT pathway (p < 0.01), indicating that BRCA1 can be involved in the regulation of the JAK-STAT pathway, which is consistent with previous evidence that BRCA1 can constitutively activate JAK-STAT signaling16 and participate in the metastasis of breast cancer17.