In a matched case-control study including 585 patients with upper aerodigestive tract cancer and 1,170 non-cancer outpatients, Oze et al.[11] determined that compared with other genotypes, the GG genotype of ADH4 rs3805322 was associated with an increased risk of upper aerodigestive tract cancer in per-allele, dominant, and recessive models. Here, ADH4 is linked to cancer.