Unconditional univariate logistic regression analysis revealed a significantly increased risk of developing ESCC in subjects with the AA genotype for rs3805322 (ADH4) compared with those with the AG (OR 1.19, 95% CI 0.89–1.61) or GG (OR 2.16, 95% CI 1.56–3.00) genotypes. The gene discussed is ADH4; the disease is esophageal squamous cell carcinoma.