IGFBP6 and HIV infectious disease: Figure 5c,d showed the methylation status of these two genes in both patients and normal subjects. In the promoter region of IGFBP6, 3 out of the 10 patients (30%) and 1 out of the normal subjects (10%) were methylated while in that of SATB2, the promoter region of 6 patients (60%) and 3 normal subject (30%) were methylated. Therefore, our results indicated that HIV infection was involved in the differential methylation and transcriptional regulation of IGFBP6 and SATB2.