Among the chemokines tested, IP10/CXCL10 and MCP-1/CCL2 were significantly higher in RR-MS patients under treatment with IFN-β (RESPONDERS) than in those patients who had been previously treated with IFN-β and did not respond to therapy and had clinical activity (NON RESPONDERS) (IP10: 111±60 vs 96±136, p = 0.04; MCP-1/CCL2: 446±158 vs 272±152, p = 0.008) (Fig 5). This evidence concerns the gene CCL2 and myeloid sarcoma.