For each analyte, an specific cut-off value: HGF >387, Eotaxin/CCL11 >132, EGF <66 and MIP-1β/CCL4 <109 pg/ml could discriminate with different sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy between a Progressive and a RR-MS patient. The gene discussed is EGF; the disease is myeloid sarcoma.