CXCL10/IP-10, CCL2/MCP-1, CCL3/MIP-1a, CCL4/MIP-1b, CCL5/Rantes, CCL7/MCP-3 and CXCL9/Mig [11–25] are among the described proinflammatory chemokines produced by immune cells and CNS glia in MS and in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). This evidence concerns the gene CCL4 and experimental autoimmune encephalomyelitis.