Currently, there is no uniform consensus on a standardized cut-off value that might be used in the clinical practice, although staining levels of 10%–20% have been the most common to dichotomize populations used [52] and in the 13th St Gallen International Breast Cancer Conference (2013) a majority of the Panel voted that a threshold of ≥20% was indicative of ‘high’ Ki-67 status [42]. Here, MKI67 is linked to breast carcinoma.