Higher CRP at baseline was significantly associated with an increased risk of all-cause mortality (HR 1.42, 1.25–1.62, p<0.0001; I2 = 64.38; Q 28.1; DF 10; p = 0.002) and cardiovascular disease (CVD) mortality (HR 1.31, 1.02–1.68, p = 0.033; I2 = 80.44; Q 10.22; DF 2; p = 0.006), but baseline CRP has no relationship with risk of coronary heart disease (CHD) mortality (HR 1.20, 0.93–1.56, p = 0.162; I2 = 71.02; Q 6.9; DF 2; p = 0.032). The gene discussed is CRP; the disease is cardiovascular disorder.