It is expressed by a variety of cell types and regulates several functions in some cell signaling pathways.27 The differentiation of both B cell and TH17 cell could be inhibited by ETS1. 7,8 Animal experiments showed that lupus-like disease could easily be developed in ETS1-deficient mice.28 Then, ETS1 was found to be associated with SLE based on human data.9,10 As the clinical and immunological overlap of SLE and other ADs,29 other researchers found the association of ETS1 and ankylosing spondylitis (AS).20 Here, ETS1 is linked to ankylosing spondylitis.