Single nucleotide polymorphisms (SNPs) or mutations in the genetic sequence may alter the expression of the gene.12–16 Some researchers paid attention to the relationship between AD risk and 2 polymorphisms of ETS1, namely ETS1 rs1128334 G>A and ETS1 rs10893872 T>C.10,17–22 However, the results remain conflicting. The gene discussed is ETS1; the disease is Alzheimer disease.