AGTR1 and cancer: Another explanation for the association of RAS signaling with cancer growth may be the trans-activation of growth factor receptors such as EGFR.13 Stimulation of AT1R trans-activates intracellular carboxyl terminus of EGFR simultaneously, independently from EGFR ligands.13 In this regard, AT1R and EGFR share a mutual downstream signaling after AT2 stimulation.