In an effort to gain insight into the potential function of KRT78, we performed phylogenetic analysis of all type II epithelial keratins and identified KRT78 as most closely related to keratin 4 (KRT4), which is downregulated in esophageal squamous cell carcinoma [22] (Fig 4C). The gene discussed is KRT4; the disease is esophageal squamous cell carcinoma.