In a recent pre-clinical trial of adult patients with EoE, anti-IL-13 therapy was demonstrated to be effective in reducing esophageal eosinophil levels and normalizing disease-associated transcript signatures, including increased DSG1 and decreased KRT14 and KRT16 levels [10]; however, the direct regulation of esophageal epithelial cell keratins by IL-13 in the context of EoE remains unaddressed. The gene discussed is DSG1; the disease is eosinophilic esophagitis.