IL13 and eosinophilic esophagitis: When compared to the RNA sequencing profile of genes dysregulated in inflamed esophageal tissue from patients with active EoE compared to healthy controls (P < 0.05, fold change > 2.0; n = 1,607), 37% (286 out of 781) of the genes altered by IL-13 in the ALI were identified (Fig 5A).