TM4SF1 and Familial prostate cancer: For example, KLK3 encoding prostate-specific antigen (PSA), TM4SF1 known to be a tumor-associated antigen, FGFR2 known to be related to growth and tumorigenicity, IFT57 among the apoptosis related genes, HIP1 as a cellular survival factor in prostate cancer, and the like, were altered by Pin1 knockdown.