We selected 14 disallowed genes for analysis based on their identification in 2 independent studies (C1qbp, Cd302, Cxcl12, Igfbp4, Ldha, Lmo4, Maf, Oat, Pdgfra, Slc16a1, and Smad3) (6, 7) and/or other criteria including up-regulation in type 2 diabetes (Acot7, Ldha, and Pdgfra) (5). Here, SMAD3 is linked to type 2 diabetes mellitus.