MYC and glioblastoma: To confirm previous reports and examine the effects of arsenic trioxide and 10058F4, an inhibitor of c-Myc on the differentiation of a newly derived GBM CSC neurosphere line (RI01; Materials and Methods), we treated dissociated neurospheres with 2μM arsenic trioxide or 60μM 10058F4 for three days in differentiating condition.