EBV EB2 (also called SM) functions as a trans-acting factor136,137 in regulating RNA splicing via its interaction with the cellular oncogenic splicing factor SRSF3 (serine/arginine-rich splicing factor 3).138 Although EBV EB2 is not expressed in the latent stage of EBV infection, increased SRSF3 expression in lymphoma might play a role in LMP1 splicing and is worth investigating. Here, MAPRE2 is linked to Epstein-Barr virus infection.