On the other hand, as known, mast cells are activated by IgE, but also by IgE-independent mechanism, cytokines, chemokines, drugs, physical stimuli and hormones, therefore, these cells are not only involved in allergic diseases but also in inflammatory conditions such as atherosclerosis [17] as well as the chemotaxis of eosinophils and other inflammatory cells involved in thrombosis pathogenesis [16]. This evidence concerns the gene IGHE and allergic disease.