Increased ubiquitylation was also observed on several sites on the transcription factor STAT3, which plays an important role in B-cell development (Wang et al, 2007), as well as on GNAI2, which is also required for B-cell development (Dalwadi et al, 2003), and mutated in Burkitt lymphoma and DLBCL (Morin et al, 2013). This evidence concerns the gene GNAI2 and diffuse large B-cell lymphoma.