Among them, MT1/MT2 isoforms are the most active in human cells and may participate as tumor regulators in such crucial mechanisms as inhibition of NF-κB signaling, modulation of p53 zinc-dependent activity, as well as regulation of the PIK3/AKT and Rb/E2F pathways [9, 10, 14–17]. This evidence concerns the gene MT2A and neoplasm.