MT2A and breast carcinoma: In another study, the same researchers also observed an increase of almost 90 % in the risk of ductal breast cancer after adjustment for inter alia age, family history, smoking status, menarche and menopausal status in subjects having one copy of the risk G allele in MT2A promoter region as well as an increase of 50 % in risk of cancer when MT2A haplotypes G-A-G was taken into account.