MT2A and neoplasm: While the −5 (rs28366003) SNP in the MT2A gene could be considered as a potential biomarker for the etiopathology and a higher susceptibility of sinonasal inverted papilloma, as well as an indicator of the dynamics of tumor growth, discrepancies shown in the discussion exist for other neoplastic lesions due to variation of tumor origins, proliferation, and histological differentiation status, which cause differences in their biology.