The herein used FGFR inhibitors TKI258 and BGJ398 are already applied in clinical trials of other tumor entities, such as FGFR3 mutated bladder cancer or squamous cell lung cancer with FGFR1 amplification (e.g. NCT01004224 or NCT01831726). The gene discussed is FGFR3; the disease is urinary bladder cancer.