In the ER+PR+ group, the HRs for BCSM increased with increasing tumor size until a threshold was reached (approximately 50 mm) (0–10 mm, HR 0.176, 95% CI 0.156–0.198, P < 0.001; 11–20 mm, HR 0.308, 95% CI 0.276–0.343, P < 0.001; 21–30 mm, HR 0.525, 95% CI 0.471–0.585, P < 0.001; 31–40 mm, HR 0.739, 95% CI 0.660–0.827, P < 0.001; 41–50 mm, HR 0.831, 95% CI 0.737–0.936, P = 0.002). Here, ESR1 is linked to neoplasm.