Through targeting multiple oncogenes and oncogenic pathways, miR-1 has been demonstrated to be a tumor suppressor gene that represses cancer cell proliferation and metastasis and promotes apoptosis by ectopic expression in lung cancer, colon cancer genitourinary cancer, head and neck cancer, thyroid cancer and hepatocellular cancer by targeting PIK3CA, MET, LASP1, TAGLN2, CCND2, FoxP1, HDAC4 and so on [10-15]. This evidence concerns the gene HDAC4 and hepatocellular carcinoma.