We also found that experimental restoration of miR-1 expression in ccRCC cells leads to suppression of CDK4, CDK6 and Caprin1, cell cycle arrest at G1/S checkpoint and disrupted proliferation of the cancer cells, whereas completely silencing miR-1 further upregulated CDK4, CDK6 and Caprin1 and promotes cell cycle progression. The gene discussed is CDK4; the disease is cancer.