In order to explore the mechanisms responsible for 14-3-3σ sensitizing TC cells to chemotherapy, we focused on GSK3β/β-catenin signaling, because our previous data suggested activation of GSK3β/β-catenin signal in multidrug resistant tongue cancer (MDR-TC) cells Tca8113/PYM [20]. The gene discussed is GSK3B; the disease is tongue cancer.