Additionally, PMS2 expression including both RNA [21] and protein [21, 22] were found to be much lower in PCa when compared to benign prostatic hyperplasia (BPH) tissue; and a significant inverse correlation between Gleason score and PMS2 expression was observed in PCa, making it a good marker of progression [21, 22]. The gene discussed is PMS2; the disease is benign prostatic hyperplasia.