As shown in Fig. 1, solid and cultured primary human GBMs, glioma-infiltrating macrophages/microglia (GIMs), human umbilical vein endothelial cells (HUVEC) (Fig. 1a) and five different GBM cell lines (Fig. 1b) were all characterized by distinct Twist-1 and Akirin-2 mRNA expression except for HUVEC, that did not express Twist-1. Here, AKIRIN2 is linked to central nervous system cancer.