Furthermore, many genes downregulated by IGSF8 knockdown are markers of neuroendocrine differentiation (OPRK1 [28, 29], PNMA2 [30], IGFBP3 [31]), cell-adhesion proteins (PCDHB10, PCDHB15, PCDHB8, PCDHB16, PCDHB18, PCDHB12, PCDHB4), targets of AR-regulated transcriptional repressor REST [32, 33], and genes associated with suppression of prostate and other cancers (SERPINI1 [34], ODZ2 [35], SI [36], TLR5 [37, 38], RNF180 [39], FBXL2 [40–42], TRIM45 [43]). The gene discussed is RNF180; the disease is cancer.