MYC and leukemia: Because Myc is necessary to drive the proliferation of virtually all transformed cells [8, 9, 46], we first examined the cell cycle effects on the above-described Myc inhibitors in HL60 promyelocytic leukemia cells, which over-express Myc due to gene amplification and which have been previously used to assess many Myc inhibitors [12, 15, 38, 48].