For example, as a repulsive cue for Plexin D1-expressing endothelial cells [11], overexpression of Sema3E inhibits tumor development via the disruption of tumor vascular patterning [13, 14, 22, 23]; similarly, recombinant Sema3E can inhibit PDGF-mediated proliferation and migration of human airway smooth muscle cells [20]. Here, SEMA3E is linked to neoplasm.