Moreover, activation of the TP53 pathway upon BCR triggering was also revealed by re-analyzing the GEP data associated with miR-132 up-regulation reported by Pede et al. [30] (RB, personal communication), and overtly reported by Tavolaro et al. [31], although not associated with the down-regulation of the miR-132 target SIRT1. Finally, using a similar GEP approach, Vallat et al [19] provided evidence for activation of a proapoptotic transcriptional program in CLL cells at later time points after BCR stimulation. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.