In the present study, we describe for the first time a complete and inter-chained cascade of events, occurring in both M and UM CLL cells, triggered by BCR engagement via miR-132 up-regulation and sequentially characterized by SIRT1 down-regulation, TP53 acetylation and TP53 pathway activation. The gene discussed is SIRT1; the disease is B-cell chronic lymphocytic leukemia.