In this regard, a more aggressive clinical course has been associated with specific features of the B-cell receptor (BCR) expressed by CLL cells, particularly the so-called unmutated (UM) configuration, i.e. less than 2% point mutations, of the genes coding for the immunoglobulin heavy-chain variable (IGHV) region of the BCR [1]. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.