microRNA profile results were validated in CLL cells from a wider series of 28 cases (12 UM and 16 M CLL), in which stimulation with immobilized anti-IgM (hereafter simply indicated as anti-IgM) resulted in a significant induction of miR-132 expression both in UM (mean fold change over control 21.6±4.9; P = 0.0015) and M CLL cells (mean fold change over control 18.2±3.1; P = 0.0001), with a comparable magnitude comparing UM and M CLL (P = 0.54; Figure 1C). The gene discussed is CD40LG; the disease is B-cell chronic lymphocytic leukemia.