A direct functional link between miR-132 and SIRT1 in CLL was demonstrated by taking advantage of the CLL-like models MEC1 and EHEB, in which an ad-hoc luciferase assay and the transfection of microRNA precursor of miR-132 clearly showed the capability of miR-132 to directly down-regulate SIRT1 expression, as also found in other cell systems [45]. This evidence concerns the gene SIRT1 and B-cell chronic lymphocytic leukemia.