Of note, among the top-ranked miR-132 target genes identified in our analysis as down-regulated by anti-IgM stimulation both in UM and M CLL cells, was SIRT1, a gene encoding for a class III nuclear deacetylase targeting several histonic and non-histonic proteins including TP53, Ku70, and FOXO [45–48]. The gene discussed is SIRT1; the disease is B-cell chronic lymphocytic leukemia.