When CLL cells (4 UM and 4 M CLL) were concomitantly exposed in vitro to anti-IgM and the SYK inhibitor R406 [36], the up-regulation of miR-132 upon anti-IgM stimulation (mean fold change over control 16.3±5.3; P = 0.023; Figure 1D) was completely abrogated (mean fold change over control 0.7±0.1; P = 0.127; Figure 1D), demonstrating the dependency of miR-132 up-regulation to BCR triggering. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.