When a luciferase reporter construct containing the SIRT1 3′-UTR was co-transfected with the pre-miR-132 in cells from the CLL-like cell line MEC1, a significant decrease in luciferase activity (mean fold change over control 0.17±0.03, P = 0.0213) was observed with respect to MEC1 cells co-transfected with the SIRT1 3′-UTR and the corresponding scrambled control (Figure 3A). Here, SIRT1 is linked to B-cell chronic lymphocytic leukemia.