INS and obesity due to melanocortin 4 receptor deficiency: Increased expression of ECM components in adipose tissue has been repeatedly reported in murine models of obesity and in obese subjects associated with either body mass index (BMI), insulin sensitivity and/or resistance, and/or inflammation (Abdennour et al., 2014; Divoux et al., 2010; Halberg et al., 2009; Khan et al., 2009; Tam et al., 2012; Walker et al., 2014).