SCO1 and Decreased liver function: Similarly, mutations causing distinct clinical phenotypes – cardioencephalopathies and hepatopathies – were found in two genes, SCO1 and SCO2, respectively, that are homologous to a yeast gene (SCO1) required for copper delivery into CIV (Leary et al., 2004; Papadopoulou et al., 1999; Valnot et al., 2000a).