However, complete cancer remissions have been reported in patients with a range of administered anti-CD19 CAR T-cell doses, with anti-CD19 CAR T cells persisting for longer than 6 months (Kalos et al., 2011; Porter et al., 2011), indicating that the ability of the cells to proliferate and persist might be more important than the initial cell dose per se. This evidence concerns the gene CD19 and cancer.