Melanoma populations maintained in epidermal growth factor (EGF)- and basic fibroblast growth factor (bFGF)-containing medium (EGF(+)bFGF(+) medium) are enriched with cells possessing stem-like characteristics as exhibited by their high clonogenicity [31], enhanced tumorigenicity [14,29], pluripotency related to increased expression of NANOG and OCT4 [14,21,30] and the ability to differentiate into multiple non-melanocytic lineages [18,29,30]. Here, FGF2 is linked to melanoma.