Previously, we reported that small interfering RNA (siRNA) targeting E6/E7 in combination with cisplatin (cis-diamminedichloroplatinum II; CDDP) exerts a synergistic effect through the restoration of TP53 and RB/E2F; moreover, it has a more potent therapeutic effect for cervical cancer than either of the agents alone have [17]. Here, TP53 is linked to cervical carcinoma.