In addition, DIM-C-pPhOH (30 mg/kg/d) also decreased expression of TXNDC5 and IDH-1 and induced CHOP expression in tumors from athymic nude mouse xenografts (Fig 5E), demonstrating that C-DIM/NR4A1 antagonists-dependent inhibition of RCC cell and tumor growth is due, in part, to induction of stress (Fig 1A). This evidence concerns the gene DDIT3 and renal cell adenocarcinoma.