Both NR4A1 knockdown and the NR4A1 antagonists inhibited ACHN and 786-O cell proliferation and transactivation, and DIM-C-pPhOH also inhibited tumor growth in athymic nude mice bearing ACHN cells as xenografts (Fig 1) and siNR4A1 and NR4A1 antagonists also induced apoptosis in these cell lines (Fig 2). The gene discussed is NR4A1; the disease is neoplasm.