ACHN and 786-O RCC cell lines are p53-positive and mutant cell lines, respectively, and in cells transfected with two different oligonucleotides that target NR4A1 (siNR4A1), there was a significant 50–60% decrease in proliferation of both cell lines (Fig 1B). The gene discussed is TP53; the disease is renal cell adenocarcinoma.