NR4A1 and renal cell adenocarcinoma: We also observed that both DIM-C-pPhOH and DIM-C-pPHCO2Me induced Annexin V staining in ACHN and 786-O cells (Fig 2C and 2D, respectively), confirming that C-DIM/NR4A1 antagonists induce apoptosis in RCC cell lines.