SEPTIN9 and colorectal carcinoma: However, no serum tumour markers have approved screening utility for CRC (Locker et al, 2006; Duffy et al, 2014), and although a recently evaluated plasma septin 9 (SEPT9) DNA methylation test (Epi proColon) holds some promise (Church et al, 2013; Johnson et al, 2014), increased uptake (vs faecal testing) in non-compliant populations needs to be demonstrated.