PLN and centronuclear myopathy: Since we observed a trend for higher MHC I (supplementary material Fig. S5C, P=0.10) and SERCA2a (supplementary material Fig. S5D, P=0.10) expression, and significant reductions in both SERCA1a (supplementary material Fig. S5E) and SLN (supplementary material Fig. S5F) in CNM muscles compared with healthy controls, it is possible that these differences, including upregulated PLN, are due mostly to the expected type I fiber predominance in CNM patients.