MTM1 and X-linked myotubular myopathy: In addition, upregulation of dynamin 2 was observed in skeletal muscles from mtm1–/y mice, which accurately models human X-linked myotubular myopathy (XLCNM), and heterozygous knockdown of dynamin 2 in the mtm1–/y mouse improves muscle pathology and function (Cowling et al., 2014).