Human monoclonal IgMs directed against β-amyloid that improved cognitive scores in mice with Alzheimer's-like disease can be found in the brain after peripheral delivery (Banks et al., 2002, 2007), and human monoclonal IgGs directed against the CNS-neuron-specific protein LINGO-1, which improves both the experimental autoimmune encephalomyelitis (EAE) and lysolecithin models of demyelination, are found within the brain and spinal cord of normal rats and rats with encephalomyelitis following intravenous administration (Pepinsky et al., 2011). This evidence concerns the gene LINGO1 and encephalomyelitis.