Many ALS-associated FUS mutations disrupt the function of the C-terminal PY domain, which serves as a nuclear localization signal (NLS) (Vance et al., 2009, , 2013; Gal et al., 2011; Dormann et al., 2010; Bosco et al., 2010; Ito et al., 2010; Kino et al., 2011). Here, FUS is linked to amyotrophic lateral sclerosis.