Finally, the almost imperceptible levels or unchanged hepatic gene expression of other IL-6-type cytokines, such as CT1, IL-11 or OMS, that could compensate the IL-6 deficiency, along with the lack of STAT3/AMPK activity and Socs3 expression in the absence of IL-6, indicated their little relevance in the physiological regulation of liver steatosis in obesogenic diet conditions. The gene discussed is SOCS3; the disease is fatty liver disease.