In agreement with previous studies, the HFD-derived effects were aggravated in IL-6-deficient mice, which showed higher weight gain, higher liver fat content associated with severe steatosis, higher cholesterol levels, and decreased TG levels in serum, further supporting the notion that IL-6 is involved in modulating the levels of lipid parameters in the liver and serum (El-Assal et al., 2004; Hong et al., 2004; Kroy et al., 2010; Matthews et al., 2010; Yamaguchi et al., 2010). Here, IL6 is linked to steatosis.