Moreover, in primary ATII cells from bleomycin-induced lung injury – a model exhibiting activated Wnt/β-catenin signaling and pulmonary fibrosis in vivo – CBR2 expression was reduced, significantly correlating with reduced pro-SFTPC, whereas ENO1, PDIA3 and T1α were increased. This evidence concerns the gene PDIA3 and pulmonary fibrosis.