Other members of this family include tau, which is involved in tauopathies and AD (Spillantini and Goedert, 2013), polyQ peptides, which underpin Huntington's disease (HD) (Imarisio et al., 2008), and TDP43, which is linked to motor neurone disease (Ling et al., 2013). This evidence concerns the gene MAPT and Huntington disease.