This comparison showed a close resemblance between the Nes-Cre Wt1co mutants and the WT1-mutant tumours, especially with respect to the ectopic muscle development signature, whereas the phenotype in the Pax8+/CreWt1co mutant kidneys more resembled the one found in WT1-wild-type Wilms' tumours. This evidence concerns the gene PAX8 and Wilms tumor.