Finally, GO terms related to kidney development (grey nodes) are found for the Pax8+/CreWt1co/co kidneys and the WT1-wild-type Wilms' tumours but not in the Nes-Cre Wt1co/co and WT1-mutant Wilms' tumour samples, consistent with an early, pre-MET, origin of these tumours. This evidence concerns the gene NES and neoplasm.