WT1 and Glomerular sclerosis: Wt1 is essential for podocyte function as shown by the development of glomerular sclerosis in mice heterozygous for the conventional knockout (Guo et al., 2002; Menke et al., 2003) and Wt1+/R394W (Gao et al., 2004; Ratelade et al., 2010) alleles.