Then, the authors compared the genome-wide expression patterns of the mouse mutant kidneys to the expression patterns of human Wilms’ tumours bearing either mutant or wild-type WT1. Interestingly, the analyses showed that the expression data from the mouse mutants in which nephron development is blocked before the MET most closely resemble those of the human WT1-mutant tumours, whereas the data from the mouse mutants with a post-MET block more closely resemble the expression pattern found in human WT1-wild-type tumours. The gene discussed is WT1; the disease is neoplasm.