However, probes detecting the 3′-UTR showed no change in response to modulation of AR signalling in PCa xenografts (Figure 2H), both in in vitro cultured cells (data not shown) or human tumours following AR blockade (Figure 2I), suggesting that AR signalling effects on SLC16A7 expression are either context or isoform dependent. This evidence concerns the gene AR and posterior cortical atrophy.