SLC16A7 and posterior cortical atrophy: Analysis of methylation profiling from a large cohort of PCa tumours (n = 304) showed that demethylation at the internal SLC16A7/MCT2 promoter region and hypermethylation at the upstream promoter is a recurrent and significant change in PCa tumours (Wilcox test p < 0.001; Figure 1A-1B).