RNA-sequencing analysis revealed a switch in SLC16A7/MCT2 isoform expression between benign and PCa tumours, defined by repression of the full-length SLC16A7/MCT2 isoform and maintained expression of an alternative isoform arising from an internal promoter (Figure 1D-1E), consistent with the reciprocal DNA methylation changes observed. This evidence concerns the gene SLC16A7 and posterior cortical atrophy.