At the promoter upstream of the full-length SLC16A7/MCT2 isoform we observed an increase in DNA methylation in prostate tumours (DMR1) and at an internal, alternative promoter for SCL16A7/MCT2 locus (DMR2) we observed recurrent demethylation in PCa compared to benign tissue, both within and between patients (Figure 1A-1B). This evidence concerns the gene SLC16A7 and posterior cortical atrophy.