According to the Oncomine database, HER3 (fold change 5.14, p-value: 1.26E-4) is significantly overexpressed in pancreatic cancer than HER2 (fold change 3.05, p-value: 5.31E-6), which strongly suggests that HER3 has a crucial role in pancreatic cancer. The gene discussed is ERBB3; the disease is familial pancreatic carcinoma.