Su et al (5) found that a higher level of cyclo-oxygenase-2 decreased the survival rate of patients through many mechanisms, such as a corresponding higher level of vascular endothelial growth factor that stimulated the growth and migration of cancer cells (6), a higher lymphatic vessel density that reduced the restriction of cancer cell invasion (7), and enhanced lymph node metastasis that accelerated the metastasis of cancer cells (8). The gene discussed is VEGFA; the disease is cancer.