Therefore, although considering that temozolomide sensitivity of glioblastoma can be modulated by different miRs independently of the regulation of MGMT expression, six miRs have been reported to be involved in the regulation of MGMT protein expression either by degrading MGMT mRNA, namely miR-181d, -767-3p, -221, -222, -603 (100,106,114,122), or affecting the MGMT protein translation, such as miR-648 (106). The gene discussed is MGMT; the disease is glioblastoma.