For instance, MGMT promoter methylation is not different among the concentric layers of glioblastoma specimens (15,88) whereas the core of the glioma often presents higher expression of MGMT protein than the peripheral areas (88), possibly because of the transcriptional activation of expression mediated by hypoxia and activation of HIF-1α pathway (14,15). The gene discussed is MGMT; the disease is central nervous system cancer.